Clinical profile and management of a Spanish single-center retrospective cohort of patients with post-chikungunya associated complications
Clinical profile and management of a Spanish single-center retrospective cohort of patients with post-chikungunya associated complications
Blog Article
Background: This study aims to describe post-chikungunya complications chronically developed cases in returning travelers from some epidemic/endemic regions, and the variables that are associated with the progression of acute or subacute cases to the chronic phase.Methods: This single-center retrospective cohort study included chikungunya fever cases treated at La Paz-Carlos III University Hospital in Madrid, Spain, April 2014 to September 2016, when the chikungunya outbreak in Latin America started through the time of its greatest impact.Results: The analysis included 119 cases.Of these, 67.2 % were male, with a median age of 41.
0 years [IQR 16.0 to 76.0] years.Only 25.6 % of the patients attended a pre-travel advice consultation.
Most patients reported arthralgias, which significantly impacted their daily quality of life (86 %).The mean duration of joint symptoms was 129.4 days, with a ORGANIC CONCORD GRAPE median of 90 days [IQR 0 to 715].Factors found to be associated with chronic arthralgia include female sex, country of infection, age at diagnosis, previous diseases, symptoms during the acute phase, pain in previously injured tendons/joints, acute phase severity, and various laboratory markers such as hemoglobin, hematocrit, total serum bilirubin, and creatinine.Progression to chronic arthralgia significantly increased the need for changes in daily activity.
Furthermore, 42.6 % of patients with chronic arthralgia reported recurrence of symptoms once they felt they had disappeared.Targeted treatment regimens led to significant improvements in these patients.Conclusions: Toys The results of this study underscore the need for: (1) comprehensive pre-travel advice; (2) effective management of patients in specialized units, alongside early diagnosis and treatment, to prevent trivialization of these viral infections; and (3) the development of interdisciplinary recommendations to assist physicians in treating patients and enhancing outcomes.